Anti-RUSC1

Anti-RUSC1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with RUSC1 from other sources has not been determined. Protein function: S1 attaches the virion to the cell membrane by interacting with human ACE2 and CLEC4M/DC-SIGNR, initiating the infection. Binding to the receptor and internalization of the virus into the endosomes of the host cell probably induces conformational changes in the S glycoprotein. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes. [The UniProt Consortium]