Anti-RFNG

Protein function: Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O- fucose residues at specific EGF-like domains resulting in enhancement of NOTCH1 activation by DLL1 and JAG1. May be involved in limb formation and in neurogenesis. [The UniProt Consortium] Recommended dilutions: WB 1:1000-2000. Cellular localization: Golgi apparatus membrane , Single-pass type II membrane protein .