Anti-RB22A

The protein encoded by this gene is a member of the RAB family of small GTPases. The GTP-bound form of the encoded protein has been shown to interact with early-endosomal antigen 1, and may be involved in the trafficking of and interaction between endosomal compartments. [provided by RefSeq, Jul 2008], Protein function: Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes (PubMed:16537905). Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (PubMed:21849477). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form (PubMed:16537905). [The UniProt Consortium] Recommended dilutions: WB 1:500-2000 ELISA 1:5000-20000. Cellular localization: Endosome membrane , Lipid-anchor . Cell membrane , Lipid-anchor . Early endosome . Late endosome . Cell projection, ruffle . Cytoplasmic vesicle . Cytoplasmic vesicle, phagosome . Cytoplasmic vesicle, phagosome membrane , Lipid-anchor , Cytoplasmic side . Recruited to phagosomes containing S.aureus or M.tuberculosis. .