Anti-RAC1, clone 1301CT276.121.104

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-F52547-0.08ML 80 µl - -

3 - 10 Werktage*

326,00 €
NSJ-F52547-0.4ML 400 µl - -

3 - 10 Werktage*

702,00 €
 
In 1X PBS, pH 7.4, with 0.09% sodium azide. Plasma membrane-associated small GTPase which cycles... mehr
Produktinformationen "Anti-RAC1, clone 1301CT276.121.104"
In 1X PBS, pH 7.4, with 0.09% sodium azide. Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. In podocytes, promotes nuclear shuttling of NR3C2, this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3. Protein function: Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. In podocytes, promotes nuclear shuttling of NR3C2, this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3. [The UniProt Consortium]
Schlagworte: Anti-TC25, Anti-RAC1, Anti-MIG5, Anti-p21-Rac1, Anti-Ras-like protein TC25, Anti-Cell migration-inducing gene 5 protein, Anti-Ras-related C3 botulinum toxin substrate 1, RAC1 Antibody
Hersteller: NSJ Bioreagents
Hersteller-Nr: F52547

Eigenschaften

Anwendung: WB, FC, IHC, ELISA
Antikörper-Typ: Monoclonal
Klon: 1301CT276.121.104
Konjugat: No
Wirt: Mouse
Spezies-Reaktivität: human, rat
Immunogen: This RAC1 antibody was produced from a mouse immunized with a KLH conjugated synthetic peptide from the human protein.
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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