Anti-RAB3A

Anti-RAB3A
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ATA-HPA003160.25 25 µl -

7 - 10 Werktage*

335,00 €
ATA-HPA003160.100 100 µl -

7 - 10 Werktage*

446,00 €
 
Protein function: Small GTP-binding protein that plays a central role in regulated exocytosis and... mehr
Produktinformationen "Anti-RAB3A"
Protein function: Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane. Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane. Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed. Stimulates insulin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells. Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9 (PubMed:27325790). Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1 (PubMed:22248876, PubMed:30599141). Plays also a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 99% and to rat: 99%
Schlagworte: Anti-RAB3A, Anti-Ras-related protein Rab-3A
Hersteller: Atlas Antibodies
Hersteller-Nr: HPA003160

Eigenschaften

Anwendung: IHC
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human
Immunogen: Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: RIKLQIWDTA GQERYRTITT AYYRGAMGFI LMYDITNEES FNAVQDWSTQ IKTYSWDNAQ VLLVGNKCDM EDERVVSSER GRQLADHLGF EFFEASAKDN INVKQTFERL VDVICEKMSE SLDTADPAVT GAKQGPQLSD QQV (ATA-APrEST85206)

Datenbank Information

KEGG ID : K07882 | Passende Produkte
UniProt ID : P20336 | Passende Produkte
Gene ID : GeneID 5864 | Passende Produkte
Protein Atlas Nr. : ENSG00000105649

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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