Anti-RAB38

Ras-related protein Rab-38 is a protein that in humans is encoded by the RAB38 gene. On the basis of human genome sequence data, the RAB38 locus on chromosome 11 is flanked proximally by tyrosinase at 11q14-q21 and distally by EED at 11q14.2-q22.3 and MYO7A at 11q13.5. In melanocytic cells RAB38 gene expression may be regulated by MITF. May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Protein function: May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes, the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991). In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes. [The UniProt Consortium]