Anti-Prealbumin (PALB, ATTR, HsT2651, TBPA, Transthyretin, TTR)

TTR encodes transthyretin, a circulating and abundant tetramer that functions as a carrier protein of thyroid hormone and retinol binding protein. Transthyretin(TTR) is mainly produced in the liver, but also in the brain and eye. Mutations in TTR cause the protein to dissociate into monomers that after misfolding assemble into amyloid fibrils deposits in a diversity of organs. TTR is also the only gene known to be associated with familial TTR amyloidosis. Familial transthyretin (TTR) amyloidosis is characterized by a slowly progressive peripheral sensorimotor neuropathy and autonomic neuropathy as well as non-neuropathic changes of cardiomyopathy, nephropathy, vitreous opacities, and CNS amyloidosis. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilutions: ELISA: 1:500, Western Blot: 1:500-1:3000, Optimal dilutions to be determined by the researcher. , Hybridoma: FO myeloma cells with spleen cells from Balb/c mice. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.