Anti-PLAP (N-Term) Rabbit Monoclonal Antibody (Clone RM317)

Placental alkaline phosphatase (PLAP) is the placenta-specific isoenzyme of AP encoded by the ALPP gene in humans. It exists as a homodimer where each monomer is composed of an N-terminal alpha-helix and a crown domain that stabilize PLAP homodimers, a Zn2+- and Mg2+-containing active site with a catalytic serine residue, and a non-catalytic metal-binding site occupied by Ca2+. PLAP is predominately expressed by syncytiotrophoblasts in the placenta and is tethered to the plasma membrane by a glycosylphosphatidylinositol (GPI) anchor. It is also present at low levels in the cervix, ovaries, and type I pneumocytes, as well as in the serum. Increased PLAP activity has been found in tumor tissue and cerebrospinal fluid (CSF) isolated from patients with intracranial germ cell tumors. Cayman's PLAP (N-Term) Rabbit Monoclonal Antibody (Clone RM317) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.Immunogen: Peptide from the N-terminal region of human PLAP. Clone Designation: RM317. Formulation: (Request formulation change), 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: IHC and WB. Cross Reactivity: (+) PLAP.