Anti-PHC3

PHC3 (Polyhomeotic Homolog 3) is a Protein Coding gene. Diseases associated with PHC3 include Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Negative and Hyperoxaluria, Primary, Type Iii. Among its related pathways are Metabolism of proteins and SUMOylation. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is PHC2. Protein function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. [The UniProt Consortium]