Protein function: Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down- regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. [The UniProt Consortium]
synthetic peptide. The epitope recognized by A302-091A-T maps to a region between residue 225 and 275 of human prostate apoptosis response protein 4 (PRKC, apoptosis, WT1, regulator) using the numbering given in entry NP_002574.2 (GeneID 5074).