Anti-PAK6

Anti-PAK6 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with PAK6 from other sources has not been determined. Protein function: Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. [The UniProt Consortium]