Anti-p57, clone YN01246m

P57 is a cell cycle suppressor and tumor suppressor, which is mainly located on maternal chromosome 11. In complete hydatidiform mole, there is no maternal gene, and p57 is negative, while in partial hydatidiform mole, there are genes of both parents, and p57 is positive. So p57 can be used as a marker for judging and differential judging of early hydatidiform mole pregnancy. Protein function: Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life. [The UniProt Consortium]