Anti-NUT

disease:A chromosomal aberration involving NUT is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15,19)(q14,p13) with BRD4 which produces a BRD4-NUT fusion protein.,disease:A chromosomal aberration involving NUT is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15,9)(q14,q34) with BRD3 which produces a BRD3-NUT fusion protein.,PTM:Phosphorylation on Ser-1026, Ser-1029 or Ser-1031 is important for cytoplasmic export.,similarity:Belongs to the FAM22 family.,subcellular location:Shuttles between nucleus and cytoplasm.,tissue specificity:Specifically expressed in testis., Protein function: Plays a role in the regulation of proliferation. Regulates TERT expression by modulating SP1 binding to TERT promoter binding sites. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000, ELISA 1:10000-20000. Cellular localization: Cytoplasm . Nucleus . Shuttles between nucleus and cytoplasm. .