Anti-NRF1

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Nuclear Respiratory Factor 1 is also known as Alpha-Pal. Efiok et al.(1994) identified genes containing NRF1-binding sequences and found that these could be classified either as cellular proliferation genes, or as genes regulating the growth-responsive metabolic pathways of energy transduction, translation, and replication. Virbasius and Scarpulla(1994) noted that the nuclear-encoded mitochondrial transcription factorTFAMcontains potential binding sites for NRF1, NRF2(GABPA) and SP1 within the promoter region. With use of binding and electrophoretic mobility shift assays, DNase footprinting, and mutation analysis of recombinant proteins, they demonstrated specific and functional binding ofNRF1andNRF2to the TFAM promoter region. Protein function: Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. [The UniProt Consortium]