Anti-NOD5

Anti-NOD5 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with NOD5 from other sources has not been determined. Protein function: Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no inhibitory function on NF- Kappa-B and type 1 interferon signaling pathways, but enhances NF- Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313). [The UniProt Consortium]