Anti-NLGNX

This gene encodes a member of the type-B carboxylesterase/lipase protein family. The encoded protein belongs to a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. The encoded protein interacts with discs large homolog 4 (DLG4). Mutations in this gene have been associated with autism and Asperger syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013], Protein function: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000. Cellular localization: Cell membrane, Single-pass type I membrane protein. Cell junction, synapse, postsynaptic density membrane.