Anti-nhr-23

Make to order. Production time: 70-80 business days. Deliverables: 1. 200 µg antigen (used as positive control), 2. 1 ml pre-immune serum (used as negative control) , 3. Rabbit polyclonal antibody, antigen affinity purified. Quality Guarantee: 1. Antibody purity > 90% confirmed by SDS-PAGE, 2. Antibody titer > 1: 64,000 confirmed by ELISA, 3. WB positive with the immunogen protein (not applicable for synthetic peptide). Applications: ELISA, WB (positive for the recombinant immunogen protein/peptide). Buffer: Preservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, pH 7.4. Protein function: Orphan nuclear receptor. Transcription factor (PubMed:11416209, PubMed:21910973, PubMed:35968765, PubMed:9521900). Modulates expression of target genes, such as Period protein homolog lin-42 and microRNA let-7, by binding to hormone response elements (HRE) (PubMed:35968765, PubMed:9521900). Involved in promoting oscillatory expression of the primary transcripts of let-7 and paralogous microRNAs miR-48, miR-84, and miR-241 (PubMed:35968765). Plays a role in normal development and required to regulate each larval molt (PubMed:11416209, PubMed:21910973, PubMed:9521900). Involved in regulating both the frequency and number of molts, acting as part of a negative feedback loop with the let-7 family of microRNAs, perhaps contributing to a self-sustaining molecular-genetic oscillator (PubMed:35968765). Positively modulates expression of collagen and hedgehog-related genes (PubMed:11416209, PubMed:21910973). Involved in development of the gonad and associated epidermal structures (PubMed:11416209, PubMed:9521900). Required in spermatogenesis, acting following the sperm/oocyte cell fate decision, downstream of the canonical sex-determination pathway (PubMed:33060131). Involved in regulating formation of the sperm-specific fibrous body-membranous organelle (FB-MO) complexes, acting independently of transcription regulator spe-44 (PubMed:33060131). [The UniProt Consortium]