Anti-Mucin 16 (MUC16, MUC-16, CA125, CA-125, Cancer Antigen 125, FLJ14303, Mucin 16 Cell Surface Ass

Anti-Mucin 16 (MUC16, MUC-16, CA125, CA-125, Cancer Antigen 125, FLJ14303, Mucin 16 Cell Surface Ass
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
M4701-95Q.100 100 µg - -

3 - 19 Werktage*

978,00 €
 
MUC-1 (Mucin-1, also episialin, MAM-6, PEM and PUM) is a 150-450kD type I transmembrane... mehr
Produktinformationen "Anti-Mucin 16 (MUC16, MUC-16, CA125, CA-125, Cancer Antigen 125, FLJ14303, Mucin 16 Cell Surface Ass"
MUC-1 (Mucin-1, also episialin, MAM-6, PEM and PUM) is a 150-450kD type I transmembrane glycoprotein that belongs to the Mucin family of molecules. It forms a protective barrier against microbes on the apical surface of most glandular epithelium, and becomes prominently displayed on tumor cells. Mature human MUC-1 is 1232aa in length. It contains an 1135aa extracellular domain (ECD) (aa24-1158), and a signal transducing 73aa cytoplasmic tail (aa1182-1255). The ECD is highly polymorphic as evidenced by a highly variable number of 20 aa O-glycosylated tandem repeats. Intracellular processing cleaves MUC-1 between Gly1097 and Ser1098, generating a noncovalently linked heterodimer that is expressed on the cell surface. The C-terminus is 22-25kD in size, while the N-terminus is highly variable (70-400kD in size), a function of the number of resident tandem repeats. Cell surface processing by TACE releases a soluble ECD fragment of variable MW. There are multiple splice variants that show massive reductions in the size of the ECD. Over (aa126-145), human MUC-1 shares < 50% aa identity with mouse MUC-1. When compared to human, mouse MUC-1 is found not to be polymorphic and possess poorly conserved tandem repeat sequences. Applications: Suitable for use in ELISA, Immunohistochemistry and Western Blot. Other applications not tested. Recommended Dilutions: Immunohistochemistry: 5-15ug/ml using immersion fixed paraffin-embedded sections of human breast, Western Blot: 1ug/ml using human lung tissue, Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Schlagworte: Anti-PUM, Anti-PEM, Anti-EMA, Anti-PEMT, Anti-KL-6, Anti-H23AG, Anti-CD227, Anti-MUC1-CT, Anti-Mucin-1, Anti-MUC1-NT, Anti-MUC1-beta, Anti-Episialin, Anti-MUC1-alpha, Anti-Mucin-1 subunit beta, Anti-Mucin-1 subunit alpha, Anti-Krebs von den Lungen-6
Hersteller: United States Biological
Hersteller-Nr: M4701-95Q

Eigenschaften

Anwendung: ELISA, IHC, WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Sheep
Spezies-Reaktivität: human
Immunogen: Recombinant corresponding to human MUC-1 expressed in E. coli (P15941).
Format: Affinity Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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