Anti-MT-CYB

Cytochrome b is a component of the ubiquinol-cytochrome c reductase complex, which is a respiratory chain that generates an electrochemical potential, coupled to ATP synthesis. The principal components of the b-c1 complex are cytochrome b, cytochrome c1, and the rieske protein. Cytochrome b posesses two heme groups, which are not covalently attached to the protein. Mutations in cytochrome b are associated with Leber's hereditary optic neuropathy and with myopathy. Protein function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. [The UniProt Consortium]