Anti-MR1 (Clone 26.5)

Major histocompatibility complex class I-related gene protein (MR1) is a non-polymorphic MHC class Ib antigen-presenting cell surface molecule that is required for T cell receptor-mediated activation of mucosal-associated invariant T (MAIT) cells. It is composed of alpha1 and alpha2 domains, which form an antigen-binding pocket, and an alpha3 domain that interacts with beta2-microglobulin. MR1 mRNA is ubiquitously expressed and, following translation, MR1 protein is localized to the endoplasmic reticulum in a partially folded state. Upon binding of a riboflavin-derived microbial antigen, MR1 undergoes a conformational change and translocates to the cell surface where it induces MAIT cell activation via an interaction with the MAIT cell T cell receptor and activates various immunomodulatory effects, including cytokine release, initiation of adaptive immune responses, and promotion of tissue repair. Cayman's MR1 Monoclonal Antibody (Clone 26.5) can be used for flow cytometry (FC), immunoprecipitation (mass spec confirmed) (IP), and Western blot (WB) applications. The antibody recognizes MR1 from human, bovine, mouse, and rat samples.Synonyms: Class I Histocompatibility Antigen-like Protein, Major Histocompatibility Complex Class I-related Gene Protein, MHC Class I-related Gene Protein. Immunogen: Recombinant fragment containing 280 amino acids from the extracellular domain of human MR1. Clone Designation: 26.5. Formulation: (Request formulation change), 100 µg of protein G-affinity purified monoclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: Mouse. Isotype: IgG2a. Applications: FC, IP (mass spec confirmed), WB. Cross Reactivity: (+) MR1. UniProt Accession #: Q95460.