Anti-MPP2

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Membrane Palmitoylated Protein 2, also called MAGUK p55 subfamily member 2, is a protein that in humans is encoded by the MPP2 gene. Palmitoylated membrane protein 2 is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 2 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction. Protein function: Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density. In CA1 pyramidal neurons, required for synaptic KCNN2- containing channel function and long-term potentiation expression. Seems to negatively regulate SRC function in epithelial cells (PubMed:19665017). [The UniProt Consortium]