Anti-MMP-17 (Matrix Metalloproteinase 17, MT4-MMP)

Matrix metalloproteinase 17 (MMP­17) is a zinc metalloproteinase that is an integral membrane protein (1). It belongs to the membrane­type MMP (MT­MMP) subfamily, and is also known as MT4­MMP. It is associated with the cell membrane by a glycosylphosphatidylinositol (GPI) anchor (1). It has the potential to function as a pro­tumor necrosis factor­alpha (TNF­alpha) convertase (2). Unlike MMP­14 (MT1­MMP), it is a poor activator of pro­MMP­2. MMP­17 is relatively poor at digesting components of the extracellular matrix but does cleave fibrinogen and fibrin (2). MMP­17 is known to activate the aggrecanase ADAMTS­4 through proteolysis (3). MMP­17 is expressed in many tissues with the highest levels seen in the brain, colon, ovary, testis, and kidney papilla (4). It has been detected in several human cancers, including gliomas, prostate carcinomas, and breast carcinomas (5). Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.