Anti-MEK7

Anti-MEK7
Aktion:

Gratis WB-Box zu jeder Arigo-Bestellung. 

*1
*1 Angebot gültig bis zum 30.04.2019
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ARG56222.100 100 µl - -

6 - 14 Werktage

483,00 €
 
Protein function: Dual specificity protein kinase which acts as an essential component of the MAP... mehr
Produktinformationen "Anti-MEK7"
Protein function: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. [The UniProt Consortium]
Schlagworte: Anti-JNKK2, Anti-MEK 7, Anti-MAP2K7, Anti-JNKK 2, Anti-SAPKK4, Anti-SAPKK-4, Anti-MAPKK 7, EC=2.7.12.2, Anti-JNK kinase 2, Anti-SAPK kinase 4, Anti-MAPK/ERK kinase 7, Anti-MAP kinase kinase 7, Anti-JNK-activating kinase 2
Hersteller-Nr: ARG56222100

Eigenschaften

Anwendung: WB
Antikörper-Typ: Polyclonal
Wirt: Rabbit
Reaktivität: Human
Immunogen: KLH-conjugated synthetic peptide around aa. 363-396 of Human MEK7
MW: 47 kD
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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