Anti-MCM7 (CDC47 homolog, P1.1-MCM3)

MCM7(Minichromosome Maintenance, s. Cerevisiae, homolog of, 7), also called CDC47, FORMERLY,, is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the , initiation of eukaryotic genome replication. The MCM7 gene is mapped on 7q22.1. MCM7 plays a , pivotal role in the G1/S phase transition, orchestrating the correct assembly of replication forks on , chromosomal DNA and ensuring that all the genome is replicated once and not more than once at each , cell cycle. The MCM7 gene contains 15 exons. The miRNAs MIR106B, MIR93, and MIR25 are , clustered in a 5-prime to 3-prime orientation within intron 13. Petrocca et al. (2008) found , that MCM7 and the precursors of microRNAs (miRNAs) MIR106B, MIR93, and MIR25, all of which , arise from intron 13 of the MCM7gene, were overexpressed with almost perfect correlation in 5 of 10 , human gastric tumors. UniProt Number: P33993, Gene ID: MCM7, Applications: Suitable for use in Western Blot, Immunohistochemistry (Paraffin) and Immunocytochemistry. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Handling: Store at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term., Avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.