Anti-MCM6 (p105MCM)

MCM6(Minichromosome maintenance, s. pombe, homolog of, 6) is a protein that in humans is encoded , by the MCM6 gene. MCM6 is one of the highly conserved mini-chromosome maintenance proteins , (MCM) that are essential for the initiation of eukaryotic genome replication. The MCM genes were , originally identified in yeast defective in minichromosome maintenance and have since been shown to , play roles in the progression of the cell cycle, many are cell division control genes. The MCM6 gene is , mapped on 2q21.3. Mcm 6 has recently been shown to interact strongly Cdt1 at defined residues, by , mutating these target residues Wei et al. observed lack of Cdt1 recruitment of Mcm2-7 to the pre-RC., An approximately 200-kb region surrounding the C/T(-13910) polymorphism in MCM6 intron 13 , functioned as an enhancer of the lactase gene promoter in intestinal cell culture. UniProt Number: Q14566, Gene ID: MCM6, Applications: Suitable for use in Western Blot, Immunohistochemistry (Paraffin and Frozen), and Immunocytochemistry. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Handling: Store at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term., Avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.