Anti-MCAD

Medium-chain fatty acyl-CoA dehydrogenase (MCAD) is a mitochondrial enzyme that catalyzes the first step in the betaoxidation of fatty acids. MCAD expression is induced during periods of fasting, when reliance on fatty acids for energy is increased. The promoter for MCAD contains a peroxisome proliferator response element (PPRE) and is regulated transcriptionally by peroxisome proliferator-activated receptor alpha (PPARalpha), a ligand-activated transcription factor involved in the regulation of lipid homeostasis. Because of this, MCAD expression can be used as a marker to evaluate the in vivo activity of PPARalpha. Human MCAD is approximately 87% homologous to porcine and rat MCAD, respectively. MCAD is expressed in liver, heart, kidney, and skeletal muscle.Synonyms: ACADM, Medium-chain Fatty Acyl-CoA Dehydrogenase, Medium-chain Specific Acyl-CoA Dehydrogenase mitochondrial. Immunogen: Full length human recombinant MCAD. Formulation: (Request formulation change), Protein A-purified polyclonal antibody. Storage Buffer: TBS, pH 7.4, with 50% glycerol, 0.1% BSA, and 0.02% sodium azide. Host: Rabbit. Applications: WB, other applications not tested. UniProt Accession #: P11310. Origin: Animal/Rabbit.