Anti-MBNL3, clone PCRP-MBNL3-1D11

Formulation: Purified Ab with BSA and Azide at 200ug/ml. Cellular Localization: Cytoplasm, Nucleus. Positive Control: HeLa or MCF7 cells. Chromosome Location: Xq26.2. Protein Function: Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction [The Uniprot Consortium]