Anti-MARK2

Anti-MARK2
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
A303-135A-T 10 µl (10 µg) -

2 - 8 Werktage*

164,00 €
A303-135A 100 µl (100 µg) -

2 - 8 Werktage*

588,00 €
 
Protein function: Serine/threonine-protein kinase involved in cell polarity and microtubule... mehr
Produktinformationen "Anti-MARK2"
Protein function: Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4, MAPT/TAU, and RAB11FIP2. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule- dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. [The UniProt Consortium]
Schlagworte: Anti-EMK1, Anti-EMK-1, Anti-Par1b, Anti-Par-1b, EC=2.7.11.1, EC=2.7.11.26, Anti-PAR1 homolog, Anti-PAR1 homolog b, Anti-ELKL motif kinase 1, Anti-Serine/threonine-protein kinase MARK2, Anti-MAP/microtubule affinity-regulating kinase 2
Hersteller: Bethyl Laboratories
Hersteller-Nr: A303-135A

Eigenschaften

Anwendung: WB, IP
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human (Erwartet: mouse, rat)
Immunogen: synthetic peptide. The epitope recognized by A303-135A-T maps to a region between residue 350 and 400 of human MAP/Microtubule Affinity-Regulating Kinase 2 using the numbering given in entry NP_001034558.2 (GeneID 2011).
Format: Antigen Affinity Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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