Anti-LSD2 (KDM1B)

KDM1B (UniProtKB/Swiss Prot entry Q8NB78), also known as LSD2, is a histone demethylase that demethylates lysine 4 of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. KDM1B is able to demethylate both mono and di methylated lysine 4 of histone H3, but has no effect on tri methylated lysine 4, mono , di or tri methylated lysine 9, mono , di or tri methylated lysine 27, mono , di or tri methylated lysine 36 of histone H3, or on mono , di or tri methylated lysine 20 of histone H4. KDM1B is also required for de novo DNA methylation of a subset of imprinted genes during oogenesis. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed.