Anti-LRRC15 Recombinant Monoclonal

LRRC15 (Leucine-Rich Repeat Containing Protein 15) is a transmembrane protein that plays a role in various cellular processes including cell adhesion and migration, extracellular matrix remodeling, regulation of immune responses, and tumor cell growth and metastasis. It is implicated in various diseases, including cancer, osteosarcoma, and fibrosis. [taken from NCBI Entrez Gene (Gene ID: 131578)]. Protein function: (Microbial infection) Modulates the ability of SARS-CoV-2 to infect host cells through interaction with the spike protein (PubMed:36228039, PubMed:36735681, PubMed:36757924). Does not act as a SARS-CoV-2 entry receptor but sequesters virions and antagonizes in trans SARS-CoV-2 infection of ACE2+ cells when expressed on nearby cells (PubMed:36228039, PubMed:36757924). [The UniProt Consortium]