Anti-Lbp

Lipopolysaccharide-binding protein(LBP),a 58kDa glycoprotein synthesized in hepatocytes,belongs to a family of lipid-binding proteins that includes bactericidal/permeability increasing protein(BPI),phospholipid ester transfer protein(PLTP),and cholesterol ester transfer protein(CETP). LBP binds to the lipidA portion of lipopolysaccharide(LPS) to facilitate the process of LPS monomerization,catalyzes the binding of LPS monomers to CD14,and promotes LPS-induced immune response. Protein function: Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:9144073). Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:24380872). [The UniProt Consortium]