Anti-LASP1 (Metastatic lymph node gene 50 protein)

LASP1(LIM and SH3 domain protein 1), also known as LASP1, is a protein that in humans is encoded by , the LASP1 gene. This gene encodes a member of a LIM protein subfamily which is characterized by a , LIM motif and a domain of Src homology region 3. This protein functions as an actin-binding protein and , possibly in cytoskeletal organization. LASP1 has been shown to interact with Zyxin. Tomasetto et al. , (1995) mapped the LASP1 gene to chromosome 17q11-q21.3 by radioactive in situ hybridization., Northern blot analysis revealed that LASP1 mRNA was expressed at a basal level in all normal tissues , examined and overexpressed in 8% of primary breast cancers. In most of these cancers, LASP1 and , ERBB2 were simultaneously overexpressed. UniProt Number: Q14847, Gene ID: LASP1, Applications: Suitable for use in Western Blot, Immunohistochemistry (Paraffin) and Immunocytochemistry. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Handling: Store at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term., Avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.