Anti-KLK6 (Neurosin, Protease M, SP59, Serine protease 18, Serine protease 9, Zyme)

KLK6(Kallikrein-related peptidase 6), also called KALLIKREIN 6, NEUROSIN, PROTEASE M, ZYME or , PRSS9, is a protein that in humans is encoded by the KLK6 gene. This gene is one of the fifteen , kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated , by steroid hormones. Northern blot analysis revealed that the PRSS9 mRNA was expressed in several , primary tumors and cell lines from mammary, prostate, and ovarian cancers, but was not detected in , any metastases of these cancers. The KLK6 gene is mapped on 19q13.41. In tissue culture, the , enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, , suggesting a potential for involvement in Alzheimer's disease. Upon cellular stress, neurosin was , released from mitochondria to the cytosol, which resulted in the increase of degraded alpha-synuclein , species. Neurosin may play a significant role in physiologic alpha-synuclein degradation and also in the , pathogenesis of synucleinopathies. UniProt Number: Q92876, Gene ID: KLK6, Applications: Suitable for use in Western Blot, Immunohistochemistry (Paraffin) and Immunocytochemistry. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Handling: Store at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term., Avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.