Anti-JDP2

JDP2 (Jun Dimerization Protein 2) is a Protein Coding gene. Diseases associated with JDP2 include Keratitis and Skeletal Muscle Cancer. Among its related pathways are Tacrolimus/Cyclosporine Pathway, Pharmacodynamics and ATF-2 transcription factor network. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is ATF3. Protein function: Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV- induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin. [The UniProt Consortium]