Anti-IRS-1

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Insulin receptor substrate 1 is a signalling adapter protein that in humans is encoded by the IRS1 gene. This gene exhibited no intrinsic enzyme activity, and it can serve as a docking protein involved in binding and activating other signal transduction molecules after being phosphorylated on tyrosine by insulin receptor kinase. IRS-1 plays a key role in transmitting signals from the insulin and insulin-like growth factor-1 (IGF-1) receptors to intracellular pathways PI3K/Akt and Erk MAP kinase pathways. It also plays important biological function for both metabolic and mitogenic (growth promoting) pathways. In addition to those, IRS-1 is a key regulator of PI3K within malignant cells. Protein function: May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit. [The UniProt Consortium]