Anti-Interleukin-12Rbeta2 Rabbit Monoclonal Antibody (Clone 093)

Interleukin-12Rbeta2 (IL-12Rbeta2) is a type I cytokine receptor that is involved in immunity. It is composed of an N-terminal immunoglobulin-like (Ig-like) domain, five fibronectin type III domains, which facilitate cytokine binding, a transmembrane domain, and an intracellular domain that contains tyrosine phosphorylation motifs. IL-12Rbeta2 is selectively expressed in T helper 1 (Th1) over Th2 cells. IL-12Rbeta2 forms a heterodimer with IL-12Rbeta1 to form the IL-12R, and forms a homodimer or heterodimers with gp130 or IL-27Ralpha to form receptors for IL-35, which all primarily act through the JAK/STAT pathway. It is the functional receptor for IL-12, as Th2 cells that express IL-12Rbeta1 are unresponsive to IL-12 stimulation. Knockout of Il12rb2 (Il12rb2-/-) prevents increases in serum IFN-gamma levels in IL-12- or LPS-stimulated mice. Il12rb2-/- mice exhibit increased disease severity in a model of relapse-remitting experimental autoimmune encephalomyelitis. SNPs in IL12RB2 are associated with chronic obstructive pulmonary disease (COPD). Cayman's Interleukin-12Rbeta2 Rabbit Monoclonal Antibody (Clone 093) can be used for ELISA.Formal Name: For immunochemical detection of IL-12Rbeta2. Synonyms: Interleukin-12R Subunit beta2, Interleukin-12 Receptor Subunit beta2. Immunogen: Recombinant mouse IL-12Rbeta2. Clone Designation: 093. Formulation: (Request formulation change), 50 or 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: 0.2 µm filtered solution in PBS. Host: Rabbit. Isotype: IgG. Applications: ELISA. Cross Reactivity: (+) IL-12Rbeta2.