Anti-IL-23 (human), Azide Free Clone B-Z23 [Mouse]

Specificity: Recognises both natural and recombinant IL-23, p19 sub-unit, Format: Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free, Working Dilution: The suggested coating concentration range below should be optimised by each laboratory for each application. ELISA: 2,5-5µg/ml, Storage: Store at +2-8°C for 12 months. For longer storage, freeze aliquots, Application Notes: This Antibody can be used as Capture in a human **** sandwich Immunoassay to detect human **** in combination with biotinylated human **** Detection Antibody (Cat n° ***.***.***). The suggested coating concentration range below should be optimised by each laboratory for each application. Protein function: Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. [The UniProt Consortium]