Anti-IL-17F (human), Azide Free Clone B-G46 [Mouse]

Specificity: Recognises both natural and recombinant IL-17F, Format: Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free, Working Dilution: The suggested coating concentration range below should be optimised by each laboratory for each application. ELISA: 1-5µg/ml ELISpot: 5-10µg/ml, Storage: Store at +2-8°C for 12 months. For longer storage, freeze aliquots, Application Notes: This Antibody can be used as Capture in a human **** sandwich Immunoassay to detect human **** in combination with biotinylated human **** Detection Antibody (Cat n° ***.***.***). The suggested coating concentration range below should be optimised by each laboratory for each application. Protein function: Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover (PubMed:11591732, PubMed:11591768, PubMed:11574464). Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (PubMed:11591732). Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation. [The UniProt Consortium]