Anti-HMGN1

HMGN1 (high-mobility group nucleosome binding domain 1) is also known as HMG14. HMGN1 and its close analog HMG17 (MIM 163910) bind to the inner side of the nucleosomal DNA to potentially alter the interaction between the DNA and the histone octamer. The two proteins may be involved in the process that maintains transcribable genes in a unique chromatin conformation. Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.