Anti-Histone H4 (C-Term) Rabbit Monoclonal Antibody (Clone RM212)

Histone H4 is one of four core histone proteins that are involved in the organization of DNA into chromatin. Histones are globular proteins with unstructured N-terminal tails and are subject to a variety of post-translational modifications (PTMs), such as methylation, acetylation, phosphorylation, and citrullination, that can influence chromatin structure and regulate gene transcription. Histone H4 PTMs function as epigenetic regulators of transcription by affecting chromatin structure and enhancing transcription factor binding, as well as play a key role in the maintenance of genomic integrity. Levels of histone H4 are increased in the inferior and middle temporal gyrus in postmortem brains from patients with Alzheimer's disease. Histone H4 (C-Term) Rabbit Monoclonal Antibody (Clone RM212) can be used for ELISA, immunocytochemistry (ICC), multiplex-based assay, and Western blot (WB) applications. The antibody recognizes the C-terminus of histone H4 independent of PTMs.Immunogen: Peptide from the C-terminal region of human histone H4. Clone Designation: RM212. Formulation: (Request formulation change), 100 µg of protein A-affinity purified monoclonal antibody.. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: ELISA, ICC, multiplex-based assays, WB. Cross Reactivity: (+) H4A independent of PTMs, (-) Other histone proteins.