Anti-Hemoblobin, clone 2B7.G10.H12

This protein A purified mouse monoclonal antibody reacts specifically with human Hemoglobin. Anti-Hemoglobin is purified from tissue culture supernatant by protein A purification. Hemoglobin antibody detects the hemoglobin tetramer composed of alpha and beta subunits. Functional adult hemoglobin (Hb) is a hetero tetramer composed of 2 alpha and 2 beta subunits (alpha2beta2). Common isoform variants of hemoglobin include HbA, HbS, HbC, and HbA-2. Sickle cell disease (SCD), thalassemias and hemoglobinopathies occur when aberrant forms of hemoglobin are expressed in children and adults. Globin gene mutations affect the structure and expression levels of Hb. Sickle cell disease and the more benign sickle cell trait are observed in more than 100 million people globally. Perhaps the most significant mutation is the E6V in the beta subunit and the cause of SCD, but other relevant isoforms of Hb are observed. Hemoglobin antibody reacts whole hemoglobin tetramer. This antibody is ideal for investigators involved in Cardiovascular and developmental biology research. Protein function: Involved in oxygen transport from the lung to the various peripheral tissues. [The UniProt Consortium]