Anti-GST pi (GST3)

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Glutathione S-transferases pi, also known as GST pi and GST3, is present in all tissues and cells, with the exception of red cells, in which only erythrocyte GST(GSTe) is observed. The gene has 7 exons and 6 introns contained within approximately 2.8 kilobases. It is mapped to chromosome 11 . Placental glutathione-S-transferase-pi mRNA is abundantly expressed in human skin. GST pi does not contribute in vivo to the formation of glutathione conjugates of acetaminophen but plays a novel and unexpected role in the toxicity of this compound. Protein function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. [The UniProt Consortium]