Anti-GKAP1

Formulation: Phosphate-buffered saline (PBS) with 50% glycerol, 0.5% BSA and 0.09% sodium azide. Identity-Mouse (%): 88%. Homologies: Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 89%, Pig - 92%, Cynomolgus monkey - 99%. IHC Verification: succeed. WB Verification: succeed. IP Verification: -. IF Verification: -. FC Verification: -. IP-MS Verification: -. Cross reactivity: Not tested. Sandwich ELISA Verification: -. Antigen ID: ABS-PP-8793. Core Sequence: YEEHKKEYED AENTSTQSKV MNKKDKRKNH QGKDRPLTVS LKDFHSEDHI SKKTEELSSS QTLSHDGGFF NRLEDDVHKI LIREKRREQL TEYNGTDNCT AHEHNQEVVL KDGRIERLKL ELERKDAEIQ KLKNVITQWE AKYKEVKARN AQLLKMLQEG EMKDKAEILL QVDESQSIKN ELTIQVTSLH AALEQERSKV KVLQAELAKY QGGRKGKRNS. Recombinant Antibody: Protein Function: Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation [The Uniprot Consortium]