Anti-GAPex5

Anti-GAPex5
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
A302-116A-T 20 µl (2 blots) -

3 - 9 Werktage

125,00 €
A302-116A-M 100 µl (10 blots) -

3 - 9 Werktage

290,00 €
A302-116A 100 µl (20 µg) -

3 - 9 Werktage

430,00 €
 
Protein function: Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide... mehr
Produktinformationen "Anti-GAPex5"
Protein function: Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras. [The UniProt Consortium]
Schlagworte: Anti-GAPVD1, Anti-GAPEX5, Anti-GAPex-5, Anti-Rab5-activating protein 6, Anti-GTPase-activating protein and VPS9 domain-containing protein 1
Hersteller: Bethyl Laboratories
Hersteller-Nr: A302-116A-T

Eigenschaften

Anwendung: WB, IP
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human (Erwartet: Mouse, Bovine)
Immunogen: synthetic peptide. The epitope recognized by A302-116A-T maps to a region between residue 700 and 750 of human GTPase activating protein and VPS9 domains 1 using the numbering given in entry BAG10470.1 (GeneID 26130).
Format: Antigen Affinity Purified

Datenbank Information

UniProt ID : Q14C86 | Suche mit UniProt ID
Gene ID GeneID 26130 | Suche mit Gene ID

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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