Anti-FOXO3

Anti-FOXO3 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with FOXO3 from other sources has not been determined. Protein function: Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post- transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation. [The UniProt Consortium]