Anti-FMR1

Anti-FMR1 antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. FMR1 antibody is human, mouse and rat reactive. Multiple isoforms of FMR1 are known to exist. Protein function: Translation repressor. Component of the CYFIP1-EIF4E- FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression. RNA- binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C). [The UniProt Consortium]