Anti-FIP1L1

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-AB-61550.60 60 µl -

7 - 16 Werktage*

198,00 €
E-AB-61550.120 120 µl -

7 - 16 Werktage*

317,00 €
E-AB-61550.200 200 µl -

7 - 16 Werktage*

525,00 €
 
This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex... mehr
Produktinformationen "Anti-FIP1L1"
This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants en Protein function: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre- mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. [The UniProt Consortium]
Schlagworte: Anti-FIP1, Anti-hFip1, Anti-FIP1L1, Anti-FIP1-like 1 protein, Anti-Factor interacting with PAP, Anti-Rearranged in hypereosinophilia, Anti-Pre-mRNA 3'-end-processing factor FIP1, FIP1L1 Polyclonal Antibody
Hersteller: Elabscience
Hersteller-Nr: E-AB-61550

Eigenschaften

Anwendung: WB, IHC, IF
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, mouse, rat
Immunogen: Recombinant protein of human FIP1L1

Handhabung & Sicherheit

Lagerung: -20°C
Versand: 4°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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