Anti-Filaggrin, clone r15C10

1 mg/ml in 1X PBS, BSA free, sodium azide free. FLG antibody targets Filaggrin, a high molecular weight structural protein encoded by the FLG gene that plays a central role in epidermal differentiation and skin barrier formation. Filaggrin is synthesized as a large profilaggrin precursor that accumulates in keratohyalin granules within the granular layer of stratified squamous epithelium. During terminal keratinocyte differentiation, profilaggrin undergoes proteolytic processing to generate multiple filaggrin monomers that bind keratin intermediate filaments in the cytoplasm, promoting filament aggregation and cellular flattening characteristic of the stratum corneum.Beyond its structural function, Filaggrin contributes to epidermal barrier integrity through further degradation into hygroscopic amino acids and derivatives collectively known as natural moisturizing factors. These breakdown products regulate skin hydration, surface pH, and antimicrobial defense. Reduced or absent filaggrin expression compromises barrier function and increases transepidermal water loss, underscoring the importance of Filaggrin in maintaining normal skin physiology.FLG antibody, also referred to as filaggrin antibody, is widely used to study epidermal differentiation, keratinocyte maturation, and skin barrier biology. Filaggrin expression is tightly restricted to differentiating keratinocytes and is most prominent in the granular layer of the epidermis, making it a useful marker for epithelial lineage characterization. Altered filaggrin expression has been strongly associated with inflammatory and hyperproliferative skin disorders, and loss-of-function FLG mutations are a major genetic risk factor for ichthyosis vulgaris and atopic dermatitis.Clone r15C10 is designed to recognize Filaggrin and supports detection of filaggrin expression and localization in research applications. Use of an FLG antibody enables investigation of epidermal differentiation status, barrier defects, and disease-associated changes in keratinocyte biology.Explore our Filaggrin Antibody / Epidermal Differentiation Marker page for additional validation data and research applications involving keratinocyte maturation, epithelial barrier biology, and dermatopathology-associated signaling pathways.