Anti-EI2BE

This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Nov 2009], Protein function: Catalyzes the exchange of eukaryotic initiation factor 2- bound GDP for GTP. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000 ELISA 1:5000-20000. Cellular localization: nucleus,cytoplasm,cytosol,eukaryotic translation initiation factor 2B complex,