Anti-Edg6

Anti- Edg6 Antibody was purified by affinity chromatography. A BLAST analysis was used to suggest cross-reactivity with Edg6 from human, mouse and rat based on 100% homology with the immunizing sequence. Cross-reactivity with Anti-Edg6 from other sources has not been determined. Anti-Sphingolipid Receptor Edg6 S1P4 detects human and mouseSphingolipid Receptor Edg6 S1P4. Edg6 is a recently cloned member of the endothelial differentiation gene (EDG) G protein-coupled receptor family. It is a receptor for the lysosphingolipid sphingosine 1-phosphate (S1P), which are structurally related lysophospholipid mediators. Binding of SPP to Edg6 activates Erk, leading to the activation of the transcription factor Elk1 and thus the mitogen-activated protein kinase (MAPK) signal transduction pathway. The protein also acts as a receptor for a lipid-derived ligand. Edg6 plays an essential role in lymphocyte cell signaling. The protein is specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung. Human Edg6 gene is intronless and is mapped to chromosome 19p13.3 at the D19S120 marker. Anti-Sphingolipid Receptor Edg6 S1P4 antibody is ideal for investigators involved in neurobiology.